Efecto del extracto de cresta de gallo, rico en ácido hialurónico, sobre los parámetros isocinéticos en personas con gonalgia leve / Effect of rooster comb extract, rich in hyaluronic acid, on isokinetic parameters in adults with mild knee pain

Introducción: La artrosis de rodilla se manifiesta en una primera fase como una gonalgia leve y produce una disminución de la fuerza muscular, que puede ser valorada objetivamente con la prueba isocinética. Dentro de su tratamiento se debe considerar el ácido hialurónico por vía oral. Objetivo: Valorar la evolución de los parámetros isocinéticos de fuerza muscular en la articulación de la rodilla con gonalgia leve antes y después del consumo de un extracto de cresta de gallo (ECG), rico en ácido hialurónico, por vía oral. Metodología: Ensayo de intervención nutricional, doble ciego, aleatorizado, controlado con placebo y en paralelo con dos grupos de tratamiento: grupo activo con ingesta de un yogur bajo en grasa con 80 mg de ECG rico en ácido hialurónico y grupo control con ingesta de un yogur bajo en grasa sin ECG. Se valoraron los parámetros isocinéticos de pico torque (PT), trabajo total (TT) y potencia media (PM) a las velocidades de 180º/seg y 240º/seg para los movimientos de flexión y extensión de la rodilla. Resultados: Después de 12 semanas del consumo del yogur, los hombres del grupo activo, en comparación con los del grupo control, obtuvieron diferencias estadísticamente significativas (p<0,05) y mejora clínica (>10%) a la velocidad de 180º/seg en el movimiento de extensión en la variable PT (p=0,048) (19,33%), TT (p=0,020) (37,97%) y PM (p=0,029) (47,25%), y en el movimiento de flexión en la variable PT (p=0,007) (25,41%), TT (p=0,014) (42,98%) y PM (p=0,022) (48,90%). Conclusión: La ingesta de un yogur bajo en graso con extracto de cresta de gallo rico en ácido hialurónico mejora la fuerza muscular de la rodilla en hombres con gonalgia leve

Background: Knee osteoarthritis manifests itself in a first phase as a mild gonalgia and produces a decrease in muscle strength, which can be objectively assessed with isokinetic testing. In the treatment of knee osteoarthritis, should be considered the hyaluronic acid orally. Objective: Assess the evolution of isokinetic parameters of muscle strength in the knee joint with mild gonalgia before and after the consumption of RCE, rich in hyaluronic acid, orally. Methodology: Nutritional intervention trial, double-blind, randomized, controlled with placebo and in parallel with two treatment groups: the active group with a low-fat yogurt with 80 mg of roster comb extract (RCE) and the control group with a low-fat yogurt without RCE. The main variables of the study were the peak torque, total work and mean power of the isokinetic valuation at the speed of 180 º/seg and 240 º/seg by the movements of flexion and extension of the knee joint. Results: After 12 weeks of consumption of yogurt, men of the active group, compared with those in the control group, obtained statistically significant differences (p <0.05) and clinical improvement (>10%) at the speed of 180º/seg in the movement extension in the PT variable (p=0.048) (19.33%), TT (p=0.020) (37.97%) and PM (p=0.029) (47.25%), and in the flexion movement in the variable PT (p=0.007) (25.41%), TT (p=0.014) (42.98%) and PM (p=0.022) (48.90%). Conclusions: The intake of a low-fat yogurt with RCE rich in hyaluronic acid improves the muscle strength of the knee in men with mild gonalgia

Effectiveness of a low-fat yoghurt supplemented with rooster comb extract on muscle strength in adults with mild knee pain and mechanisms of action on muscle regeneration.

PURPOSE: To determine the effects of the intake of low-fat yoghurt supplemented with rooster comb extract (RCE) on muscle strength. METHODS AND RESULTS: 148 subjects, with mild knee pain, participated in a randomized, placebo-controlled, double-blind, and parallel study. Muscle strength, knee effusion, and pain perception were measured. C2C12 myoblasts were used to elucidate the mechanisms of action involved. RCE improved total work and mean power in men, and also peak torque in extension by 10%. RCE reduced synovial effusion by 11.8% and pain perception by 24.6%. Both RCE and HA increased myoblast proliferation by 29%, while RCE reduced myoblast differentiation by 36.2%, suggesting a beneficial role of RCE in muscle regeneration. CONCLUSIONS: Low-fat yoghurt supplemented with RCE improved muscle strength. This effect is partially explained by muscle regeneration enhancement, reduced synovial effusion, and reduced pain perception, which could exert a beneficial clinical impact on men affected by mild knee pain.

A low-fat yoghurt supplemented with a rooster comb extract on muscle joint function in adults with mild knee pain: a randomized, double blind, parallel, placebo-controlled, clinical trial of efficacy.

Preliminary results suggested that oral-administration of rooster comb extract (RCE) rich in hyaluronic acid (HA) was associated with improved muscle strength. Following these promising results, the objective of the present study was to evaluate the effect of low-fat yoghurt supplemented with RCE rich in HA on muscle function in adults with mild knee pain; a symptom of early osteoarthritis. Participants (n = 40) received low-fat yoghurt (125 mL d(-1)) supplemented with 80 mg d(-1) of RCE and the placebo group (n = 40) consumed the same yoghurt without the RCE, in a randomized, controlled, double-blind, parallel trial over 12 weeks. Using an isokinetic dynamometer (Biodex System 4), RCE consumption, compared to control, increased the affected knee peak torque, total work and mean power at 180° s(-1), at least 11% in men (p < 0.05) with no differences in women. No dietary differences were noted. These results suggest that long-term consumption of low-fat yoghurt supplemented with RCE could be a dietary tool to improve muscle strength in men, associated with possible clinical significance. However, further studies are needed to elucidate reasons for these sex difference responses observed, and may provide further insight into muscle function.